Su I-hsin, Tarakhovsky Alexander
Laboratory of Lymphocyte Signaling, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.
Curr Opin Immunol. 2006 Apr;18(2):152-7. doi: 10.1016/j.coi.2006.01.012. Epub 2006 Feb 7.
A combination of various post-translational modifications regulates the formation of signaling networks in both the nucleus and the cytosol. Of these, lysine methylation provides a relatively stable marker on histones and contributes to the formation of a distinct pattern of histone-dependent gene regulation ('transcriptional memory'). Thus far, lysine methylation was considered to be nucleus specific; however, recent findings indicate that lysine methylation contributes to receptor-mediated signal transduction in the cytosol.
多种翻译后修饰的组合调节细胞核和细胞质中信号网络的形成。其中，赖氨酸甲基化在组蛋白上提供了一个相对稳定的标记，并有助于形成一种独特的依赖组蛋白的基因调控模式（“转录记忆”）。迄今为止，赖氨酸甲基化被认为是细胞核特有的；然而，最近的研究结果表明，赖氨酸甲基化有助于细胞质中受体介导的信号转导。
