Rupasinghe Chamila N, Spaller Mark R
Department of Chemistry, Wayne State University, Detroit, MI 48202, USA.
Curr Opin Chem Biol. 2006 Jun;10(3):188-93. doi: 10.1016/j.cbpa.2006.03.014. Epub 2006 Apr 17.
The two most lauded drug design approaches from the past century--structure-based design and combinatorial chemistry--are increasingly experiencing integration, whereby the three-dimensional coordinates of a receptor supports the development of combinatorial-based ligand design. A selective polling of the recent literature demonstrates that this can be actualized in many ways.
过去一个世纪里最受赞誉的两种药物设计方法——基于结构的设计和组合化学——正日益走向融合，即受体的三维坐标支持基于组合的配体设计的开发。对近期文献的一项选择性调查表明，这可以通过多种方式实现。
