Koeda Michihiko, Takahashi Hidehiko, Yahata Noriaki, Matsuura Masato, Asai Kunihiko, Okubo Yoshiro, Tanaka Hiroshi
Department of Bioinformatics, Medical Research Institute, Tokyo, Japan.
Biol Psychiatry. 2006 May 15;59(10):948-57. doi: 10.1016/j.biopsych.2006.01.013. Epub 2006 Apr 17.
Neuroimaging studies have demonstrated either reduced left-lateralized activation or reversed language dominance in schizophrenia. These findings of left hemispheric dysfunction could be attributed to language processing tasks, which activate mainly left hemispheric function. Recent functional magnetic resonance imaging studies reported right-lateralized temporal activation by human voice perception, but few studies have investigated activation by human voice in schizophrenia. We aimed to clarify the cerebral function of language processing in schizophrenia patients by considering cerebral activation of human voice perception.
Fourteen right-handed schizophrenia patients and 14 right-handed controls with matched handedness, sex, and education level were scanned by functional magnetic resonance imaging while listening to sentences (SEN), reverse sentences (rSEN), and identifiable non-vocal sounds (SND).
Under the SEN-SND and SEN-rSEN contrasts including language processing, patients showed less activation of the left hemisphere than controls in the language-related fronto-tempo-parietal region, hippocampus, thalamus and cingulate gyrus. Under the rSEN-SND contrast including human voice perception, patients showed less activation than controls in the right-lateralized temporal cortices and bilateral posterior cingulate.
Our results indicate that schizophrenia patients have impairment of broader bilateral cortical-subcortical regions related to both the semantic network in the left hemisphere and the voice-specific network in the right hemisphere.
神经影像学研究表明，精神分裂症患者存在左半球激活减少或语言优势反转的情况。左半球功能障碍的这些发现可能归因于语言处理任务，该任务主要激活左半球功能。最近的功能磁共振成像研究报告了人类语音感知引起的右侧颞叶激活，但很少有研究调查精神分裂症患者对人类语音的激活情况。我们旨在通过考虑人类语音感知的大脑激活来阐明精神分裂症患者语言处理的脑功能。
对14名右利手精神分裂症患者和14名年龄、性别、教育程度相匹配的右利手对照者进行功能磁共振成像扫描，让他们听句子（SEN）、倒序句子（rSEN）和可识别的非语音声音（SND）。
在包括语言处理的SEN-SND和SEN-rSEN对比中，患者在与语言相关的额颞顶叶区域、海马体、丘脑和扣带回中，左半球的激活比对照组少。在包括人类语音感知的rSEN-SND对比中，患者在右侧颞叶皮质和双侧后扣带回中的激活比对照组少。
我们的结果表明，精神分裂症患者在与左半球语义网络和右半球语音特异性网络相关的更广泛的双侧皮质-皮质下区域存在损伤。
