Lijffijt Marijn, Moeller F Gerard, Boutros Nash N, Burroughs Scott, Lane Scott D, Steinberg Joel L, Swann Alan C
Department of Psychiatry and Behavioral Sciences, University of Texas at Houston, TX, USA.
J Psychophysiol. 2009;23(2):52-62. doi: 10.1027/0269-8803.23.2.52.
P50, N100, and P200 auditory sensory gating reflect distinct mechanisms involved in protecting the integrity of higher-order functions. They have been implicated in multiple psychiatric disorders. Recent studies showed the (limited) effects of age and gender on sensory gating in control subjects, suggesting there may be other sources of variance. Two potential sources may be education and intelligence (intellectual capability), variables that frequently differ across studies and across experimental groups. We explored potential effects of age, gender, education, and intelligence (Shipley intelligence scale) on P50, N100, and P200 sensory gating measured with the paired-click paradigm in 60 healthy subjects recruited from the general population. Increased intellectual capability related to stronger N100 and P200 gating and more pronounced N100 and P200 amplitudes. In addition, increased age related to weaker P200 gating and smaller P200 amplitudes. Gender had negligible effects. Intellectual capability or age could contribute to variation in N100 or P200 auditory sensory gating and should be controlled for when studying sensory gating in clinical and control groups.
P50、N100和P200听觉感觉门控反映了参与保护高阶功能完整性的不同机制。它们与多种精神疾病有关。最近的研究表明，年龄和性别对对照组受试者的感觉门控有（有限的）影响，这表明可能存在其他变异来源。两个潜在来源可能是教育程度和智力（智能水平），这些变量在不同研究和不同实验组之间经常存在差异。我们在从普通人群中招募的60名健康受试者中，采用配对点击范式，探讨了年龄、性别、教育程度和智力（希普利智力量表）对P50、N100和P200感觉门控的潜在影响。智力水平提高与更强的N100和P200门控以及更明显的N100和P200波幅相关。此外，年龄增加与较弱的P200门控和较小的P200波幅相关。性别影响可忽略不计。智力水平或年龄可能导致N100或P200听觉感觉门控的变异，在临床组和对照组研究感觉门控时应加以控制。
