Simpson R H, Clarke T J, Sarsfield P T, Gluckman P G, Babajews A V
Postgraduate Medical School, University of Exeter, UK.
Histopathology. 1991 Aug;19(2):121-9. doi: 10.1111/j.1365-2559.1991.tb00002.x.
Six cases of polymorphous low-grade adenocarcinoma (terminal duct adenocarcinoma) of the minor salivary glands are presented. In all but one there was a history of a painless intra-oral mass of fairly long duration. The histopathological appearances were characterized by cytological uniformity in a variety of morphological patterns, including tubular, solid, fascicular and cribriform areas. At a cellular level, the tumours possessed regular, often vesicular nuclei and generally eosinophilic cytoplasm. Five of the patients are still alive, although one had recurrent disease 16 years after her original operation; none died of their tumour. These findings are compared with those of six salivary adenoid cystic carcinomas, a neoplasm with many similar histological features, but with a much worse prognosis. The microscopic differences were mainly cytological and, to a lesser extent, morphological. The immunohistochemical reactions of the two tumours were not sufficiently dissimilar to be of practical value. Polymorphous low-grade adenocarcinoma has only rarely been reported in Britain, but we believe it deserves wider recognition as a distinct clinicopathological entity and, in particular, separation from adenoid cystic carcinoma.
本文报告了6例小涎腺多形性低度恶性腺癌（终末导管腺癌）。除1例患者外，其余患者均有持续时间较长的无痛性口腔内肿物病史。组织病理学表现的特征为，在多种形态学模式中，包括管状、实性、束状和筛状区域，细胞具有一致性。在细胞水平上，肿瘤细胞核规则，常呈泡状，细胞质一般为嗜酸性。5例患者仍然存活，尽管其中1例在初次手术后16年出现疾病复发；无患者死于肿瘤。将这些结果与6例涎腺腺样囊性癌进行比较，腺样囊性癌是一种具有许多相似组织学特征但预后差得多的肿瘤。微观差异主要在细胞学方面，形态学差异较小。这两种肿瘤的免疫组化反应差异不足以具有实际价值。多形性低度恶性腺癌在英国仅有极少的报道，但我们认为它作为一种独特的临床病理实体，尤其应与腺样囊性癌区分开来，值得更广泛的认识。
