Darling Mark R, Schneider Johann W, Phillips Vincent M
Division of Oral Pathology, School of Oral Health, Faculty of Health Sciences, University of Stellenbosch, Private Bag X1, Tygerberg 7505, South Africa.
Oral Oncol. 2002 Oct;38(7):641-5. doi: 10.1016/s1368-8375(02)00003-9.
Polymorphous low-grade adenocarcinoma (PLGA) and adenoid cystic carcinoma (ACC) have several overlapping histological patterns, including cribriform, tubular and solid patterns. The overlapping clinicopathological features of PLGA and ACC may result in a diagnostic pitfall. ACC has a much worse prognosis than PLGA, making differentiation important for therapeutic and prognostic purposes. Histopathological features remain the most reliable criteria to distinguish between these two tumours. Although PLGA and ACC have many features in common, PLGA is uncommon in the major salivary glands. Histopathological distinction is therefore mainly a problem in tumours of minor salivary gland origin where small biopsies often contribute to diagnostic difficulties. This paper reviews studies which have utilised several immunohistochemical markers in attempts to distinguish between PLGA and ACC, and also studies which have focussed on the two tumours individually. The potential discriminating value of immunohistochemistry between cases of PLGA and ACC still remains controversial.
多形性低度恶性腺癌（PLGA）和腺样囊性癌（ACC）具有几种重叠的组织学模式，包括筛状、管状和实性模式。PLGA和ACC重叠的临床病理特征可能导致诊断陷阱。ACC的预后比PLGA差得多，因此鉴别对于治疗和预后目的很重要。组织病理学特征仍然是区分这两种肿瘤最可靠的标准。虽然PLGA和ACC有许多共同特征，但PLGA在大唾液腺中并不常见。因此，组织病理学鉴别主要是小唾液腺来源肿瘤的问题，在这些肿瘤中，小活检常常导致诊断困难。本文综述了利用几种免疫组化标志物试图区分PLGA和ACC的研究，以及分别关注这两种肿瘤的研究。免疫组化在PLGA和ACC病例之间的潜在鉴别价值仍存在争议。
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