Ohye Hidemi, Nishihara Eijun, Sasaki Ichiro, Kubota Sumihisa, Fukata Shuji, Amino Nobuyuki, Kuma Kanji, Miyauchi Akira
Department of Internal Medicine, Kuma Hospital, Kobe.
Intern Med. 2006;45(6):385-9. doi: 10.2169/internalmedicine.45.1506. Epub 2006 Apr 17.
We report four cases of Graves' disease that developed after painful Hashimoto's thyroiditis. All were middle-aged women, who had high titers of anti-thyroid antibodies and thyrotoxicosis at the onset of painful Hashimoto's thyroiditis. After 2 to 7 years, they developed Graves' disease with positive antibody against the thyrotropin receptor. Their clinical courses of Graves' disease went favorably due to the treatment with antithyroid drug or radioactive iodine therapy. Painful Hashimoto's thyroiditis is an atypical variant of Hashimoto's thyroiditis and is one form of destructive thyroiditis. Thyroid damage due to painful Hashimoto's thyroiditis may be associated with the development of Graves' disease.
我们报告了4例在疼痛性桥本甲状腺炎后发生的格雷夫斯病。所有患者均为中年女性，在疼痛性桥本甲状腺炎发病时抗甲状腺抗体滴度高且存在甲状腺毒症。2至7年后，她们发展为促甲状腺素受体抗体阳性的格雷夫斯病。由于使用抗甲状腺药物或放射性碘治疗，她们格雷夫斯病的临床病程进展顺利。疼痛性桥本甲状腺炎是桥本甲状腺炎的一种非典型变体，是破坏性甲状腺炎的一种形式。疼痛性桥本甲状腺炎所致的甲状腺损伤可能与格雷夫斯病的发生有关。
