Iamaroon Anak, Boonyawong Pattriyaporn, Klanrit Poramaporn, Prasongtunskul Suwan, Thongprasom Kobkan
Department of Odontology & Oral Pathology, Faculty of Dentistry, Chiang Mai University, Thailand.
J Oral Sci. 2006 Mar;48(1):43-6. doi: 10.2334/josnusd.48.43.
Pemphigus vulgaris (PV) is a serious mucocutaneous disease that be fatal if left untreated. The oral mucosa is often the first site to be affected by the disease. It is thus important that the dentist is able to recognize oral manifestations of PV and refer appropriately. Although oral PV is a well-characterized condition, the disease characteristics of patients in Thailand have not been previously reported. Here, we describe patient and lesion characteristics of 18 cases of oral PV. For these 18 cases, the mean age was 38 years, and the male:female ratio was 1:2. The most commonly affected sites were the gingiva and buccal mucosa, and the duration of disease was approximately one year. Medications previously used included corticosteroids and interferon, and nine patients reported systemic disease. Histopathologic examination with/without direct immunofluorescence was the method of diagnosis in all cases.
寻常型天疱疮（PV）是一种严重的黏膜皮肤疾病，若不治疗可能会致命。口腔黏膜通常是该疾病首先累及的部位。因此，牙医能够识别PV的口腔表现并进行适当转诊非常重要。尽管口腔PV是一种特征明确的疾病，但泰国患者的疾病特征此前尚未见报道。在此，我们描述了18例口腔PV患者的患者及病损特征。这18例患者的平均年龄为38岁，男女比例为1:2。最常受累的部位是牙龈和颊黏膜，病程约为一年。此前使用的药物包括皮质类固醇和干扰素，9例患者报告有全身性疾病。所有病例均采用组织病理学检查及/或直接免疫荧光检查进行诊断。
