Shamim T, Varghese V Ipe, Shameena P M, Sudha S
Department of Oral Pathology and Microbiology, Govt. Dental College, Calicut.
Indian J Pathol Microbiol. 2007 Jul;50(3):498-501.
Pemphigus vulgaris (PV) is a vesiculobullous lesion that produces intraepithelial blisters in skin and mucous membrane. The oral mucosa is often the first site to be affected by the disease. Although oral PVis a well characterized condition, the detailed clinical and histopathological study in Malabar population has not been reported. A clinicopathologic study of 20 cases of oral PV observed over a span of 2 years from January 2004 to January 2006 is reported. For these 20 cases, the mean age was 42.3 years and male:female ratio was 2:3. The most commonly affected sites were the buccal mucosa and palate. Histopathologic examination with direct immunofluorescence was the method of diagnosis in all cases. Suprabasilar clefting with acantholytic cells can be seen histopathologically and IgG positivity in direct immunofluorescence in all cases that have been studied.
寻常型天疱疮（PV）是一种水疱大疱性病变，可在皮肤和黏膜产生上皮内水疱。口腔黏膜常是该疾病首先受累的部位。尽管口腔PV是一种特征明确的病症，但在马拉巴尔人群中尚未有详细的临床和组织病理学研究报告。本文报道了一项对2004年1月至2006年1月这两年间观察到的20例口腔PV病例的临床病理研究。这20例患者的平均年龄为42.3岁，男女比例为2:3。最常受累的部位是颊黏膜和腭部。所有病例均采用直接免疫荧光组织病理学检查进行诊断。组织病理学可见基底上裂隙及棘层松解细胞，且在所有研究病例的直接免疫荧光检查中均可见IgG阳性。
