Jain Varun R, Mahajan Rashmi S, Rathi Shreya S, Biyani Vinaykumar V, Ninama Kishan R, Marfatia Yogesh S
Department of Skin and VD, SBKS Medical Institute and Research Centre, Waghodia, Gujarat, India.
Indian Dermatol Online J. 2023 Mar 3;14(2):213-220. doi: 10.4103/idoj.idoj_203_22. eCollection 2023 Mar-Apr.
Diagnosing and treating oral cavity lesions is a challenging task for most of the clinicians due to similar symptoms and clinical appearances. Frequently, histopathology and immunohistochemistry aid in making the diagnosis.
The objectives were to describe the clinical features, and histopathological features and systemic association in patients with oral mucosal lesions (OML).
A cross-sectional descriptive study was undertaken at a tertiary care centre in patients with OML. A total of 369 cases with OML were included in the study.
Males constituted 61.78% of the cases. History of habits such as tobacco, gutka chewing, smoking, and alcohol was given by 32.25%, 29.81%, 26.56%, and 11.38% of cases, respectively. Common symptoms were soreness, burning sensation, oral pain and ulcers. Both oral and cutaneous involvement was seen in 17.89% of cases. Oral lichen planus (oral LP) constituted largest group of patients (21.96%) wherein reticulate type was the most frequent type and buccal mucosa was the commonest site. Oral carcinomas constituted 20.33% of cases followed by infective etiology (11.92%), vesiculobullous group of diseases (10.30%), aphthous stomatitis (8.94%), premalignant lesions (7.05%) such as leukoplakia (3.80%) and submucous fibrosis (2.44%). Histopathology was done in 209 cases. Clinico-histopathological correlation was seen in oral LP (90.27%), oral pemphigus (82.35%), and malignancies (98.66%).
Oral LP formed the largest group of cases followed by Oral squamous cell carcinoma (SCC). Several rare conditions, such as Melkersson-Rosenthal syndrome and blue rubber bleb nevus syndrome were also a part of the study. Thorough clinical and histopathological examination in this diverse group of diseases clinches the diagnosis.
由于症状和临床表现相似，对大多数临床医生而言，诊断和治疗口腔病变是一项具有挑战性的任务。组织病理学和免疫组织化学常常有助于做出诊断。
描述口腔黏膜病变（OML）患者的临床特征、组织病理学特征及全身关联。
在一家三级医疗中心对OML患者进行了一项横断面描述性研究。该研究共纳入369例OML病例。
男性占病例的61.78%。分别有32.25%、29.81%、26.56%和11.38%的病例有烟草、嚼古特卡、吸烟和饮酒等习惯史。常见症状为酸痛、烧灼感、口腔疼痛和溃疡。17.89%的病例出现口腔和皮肤受累。口腔扁平苔藓（口腔LP）患者组人数最多（21.96%），其中网状型最为常见，颊黏膜是最常见的部位。口腔癌占病例的20.33%，其次是感染性病因（11.92%）、水疱大疱性疾病组（10.30%）、复发性阿弗他口炎（8.94%）、癌前病变（7.05%），如白斑（3.80%）和黏膜下纤维化（2.44%）。对209例病例进行了组织病理学检查。在口腔LP（90.27%）、口腔天疱疮（82.35%）和恶性肿瘤（98.66%）中可见临床与组织病理学的相关性。
口腔LP病例数最多，其次是口腔鳞状细胞癌（SCC）。一些罕见疾病，如梅克尔森 - 罗森塔尔综合征和蓝色橡皮疱痣综合征也是该研究的一部分。对这一多样的疾病组进行全面的临床和组织病理学检查可确诊。
