磷酸钙同种异体移植物复合材料在生理溶液中的水解作用。

Hydrolyses of calcium phosphates-allografts composite in physiological solutions.

作者信息

Nomoto Takuya, Haraguchi Keiji, Yamaguchi Shunro, Sugano Nobuhiko, Nakayama Hirokazu, Sekino Tohru, Niihara Koichi

机构信息

Institute of Scientific and Industrial Research, Osaka University, 8-1 Mihogaoka, Ibaraki, Osaka 567-0047, Japan.

出版信息

J Mater Sci Mater Med. 2006 Apr;17(4):379-85. doi: 10.1007/s10856-006-8242-x.

DOI:10.1007/s10856-006-8242-x

PMID:16617417

Abstract

Hydrolysis of calcium phosphates cement- allografts composite in calf serum and that in saline were examined in comparison with those of the calcium phosphates cement in both the solutions. The calcium phosphates cement consists of alpha-tricalcium phosphate (alpha-TCP), tetracalcium phosphate (TetCP), dicalcium phosphate dihydrate (DCPD), and hydroxyapatite (HAP), which is clinically used as Biopex. In the hydrolyses of Biopex-allografts composite in both the solutions, the calcium phosphates cement was transformed into HAP. On the other hand, in the hydrolyses of Biopex, HAP was formed after 1 day and octacalcium phosphate (OCP) was gradually formed after 7 days. In the presence of allografts, plate-like crystals were deposited and in the absence of allografts, needle-like crystals were deposited in both the solutions. By the addition of allografts, the hydrolysis process of the calcium phosphates cement was significantly changed.

摘要

研究了磷酸钙骨水泥-同种异体移植物复合材料在小牛血清和盐溶液中的水解情况，并与磷酸钙骨水泥在这两种溶液中的水解情况进行了比较。磷酸钙骨水泥由α-磷酸三钙（α-TCP）、磷酸四钙（TetCP）、二水磷酸二钙（DCPD）和羟基磷灰石（HAP）组成，临床上用作Biopex。在两种溶液中Biopex-同种异体移植物复合材料的水解过程中，磷酸钙骨水泥转变为HAP。另一方面，在Biopex的水解过程中，1天后形成HAP，7天后逐渐形成磷酸八钙（OCP）。在两种溶液中，存在同种异体移植物时会沉积片状晶体，不存在同种异体移植物时会沉积针状晶体。通过添加同种异体移植物，磷酸钙骨水泥的水解过程发生了显著变化。