Oda Makoto, Takeuchi Akari, Lin Xin, Matsuya Shigeki, Ishikawa Kunio
Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Dent Mater J. 2008 Sep;27(5):672-7. doi: 10.4012/dmj.27.672.
Effects of liquid phase on the basic properties of alpha-tricalcuim phosphate (alpha-TCP)-based cement, BIOPEX, were investigated by employing three liquid phases: distilled water, neutral sodium hydrogen phosphate solution, and succinic acid disodium salt solution containing sodium salt of chondroitin sulfate. When mixed with neutral sodium hydrogen phosphate or succinic acid disodium salt solution, the initial setting times of the cement were 19.4 +/- 0.55 and 11.8 +/- 0.45 minutes respectively. These setting times were much shorter than that of distilled water, 88.4 +/- 0.55 minutes. Formation of needle-like crystals typical of apatite was much faster when neutral sodium hydrogen phosphate solution was used, as compared to distilled water or succinic acid disodium salt solution. Moreover, at 24 hours after mixing, the largest amount of apatite was formed when neutral sodium hydrogen phosphate solution was used, whereas use of succinic acid resulted in the least. On the final mechanical strength of the cement, that yielded with neutral sodium hydrogen phosphate solution was the highest. In contrast, lower mechanical strength was observed--especially at the initial stage--when succinic acid sodium salt was used. It was thus concluded that alpha-TCP-based cement allowed accelerated transformation to apatite, and that higher mechanical strength since the initial stage was achieved when neutral sodium hydrogen phosphate solution was used as the liquid phase.
蒸馏水、中性磷酸氢钠溶液和含有硫酸软骨素钠盐的丁二酸钠溶液，研究了液相对基于α-磷酸三钙（α-TCP）的骨水泥BIOPEX基本性能的影响。当与中性磷酸氢钠或丁二酸钠溶液混合时，该骨水泥的初凝时间分别为19.4±0.55分钟和11.8±0.45分钟。这些凝结时间比蒸馏水的凝结时间88.4±0.55分钟短得多。与蒸馏水或丁二酸钠溶液相比，使用中性磷酸氢钠溶液时，典型的针状磷灰石晶体形成得更快。此外，在混合后24小时，使用中性磷酸氢钠溶液时形成的磷灰石量最大，而使用丁二酸时形成的磷灰石量最少。关于骨水泥的最终机械强度，使用中性磷酸氢钠溶液时产生的强度最高。相比之下，使用丁二酸钠盐时观察到较低的机械强度，尤其是在初始阶段。因此得出结论，基于α-TCP的骨水泥允许加速向磷灰石转变，并且当使用中性磷酸氢钠溶液作为液相时，从初始阶段就实现了更高的机械强度。
