Perko Zdravko, Durdov Merica Glavina, Druzijanić Nikica, Kraljević Damir, Juricić Josko
University Department of Surgery, University Hospital Split, Split, Croatia.
Coll Antropol. 2006 Mar;30(1):243-6.
A 45-year old female had a long history of slow growing perianal tumor at the right side of her anus. Encapsulated tumour was found intraoperatively and completely excised using the Harmonic Scalpel. Tumour was well-circumscribed and relatively firm; measuring 12x6x4 cm. Histologically it was composed of oval to spindle cells with minimal nuclear atypia, set in mucous matrix with numerous thin-walled blood vessels. Immunohistochemically, expression of smooth-muscle actin and desmin, as well as estrogen and progesterone receptor were found in the tumour cells. The diagnosis of angiomyofibroblastoma was established. This rare benign tumour typically involves vulvovaginal, pelvic and perinal region. It is important to separate this neoplasm from locally invasive aggressive angiomyxoma and low grade fibromyxoid sarcoma, which can arise in the the same localisation. The patient was discharged on the third postoperative day and no recurrence was noted in 18 months follow-up.
一名45岁女性，肛门右侧有一生长缓慢的肛周肿瘤病史较长。术中发现为包膜完整的肿瘤，使用超声刀将其完整切除。肿瘤边界清晰，质地相对较硬；大小为12×6×4厘米。组织学上，肿瘤由椭圆形至梭形细胞组成，核异型性极小，位于含有大量薄壁血管的黏液基质中。免疫组化显示，肿瘤细胞中存在平滑肌肌动蛋白、结蛋白以及雌激素和孕激素受体的表达。诊断为血管肌成纤维细胞瘤。这种罕见的良性肿瘤通常累及外阴阴道、盆腔和肛周区域。将该肿瘤与可发生于同一部位的局部侵袭性侵袭性血管黏液瘤和低级别纤维黏液样肉瘤相鉴别很重要。患者术后第三天出院，随访18个月未见复发。
