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巨大骨盆部血管肌纤维母细胞瘤:病例报告及文献复习。

Giant pelvic angiomyofibroblastoma: case report and literature review.

机构信息

Department of Endocrinology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, People's Republic of China.

出版信息

Diagn Pathol. 2014 Jun 3;9:106. doi: 10.1186/1746-1596-9-106.

DOI:10.1186/1746-1596-9-106
PMID:24894537
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4066829/
Abstract

UNLABELLED

Angiomyofibroblastoma (AMF) is a rare, benign, soft-tissue tumor, which predominantly occurs in the vulvovaginal region of middle-aged women. It is clinically important to distinguish an AMF from other stromal cell lesions. Here, we report the case of a 32-year-old woman with a rare, giant pelvic AMF, which showed a benign clinical course. The tumor was located in the cul-de-sac of Douglas. It was well demarcated, hypocellular, edematous and composed of spindle-shaped and oval stromal cells aggregating around thin-walled blood vessels. The tumor cells had abundant eosinophilic cytoplasm, and expressed estrogen receptors, progesterone receptors and desmin. Mitotic figures were absent. It is important to distinguish AMFs from aggressive angiomyxomas because both occur at similar sites but show different clinical behaviors. Most AMFs and aggressive angiomyxomas have the same immunohistochemical phenotype. The well-circumscribed borders of AMF are the most important characteristic that distinguish it from aggressive angiomyxomas. AMFs rarely recur after complete surgical excision.

VIRTUAL SLIDES

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/5510813471244189.

摘要

未注明

血管肌纤维母细胞瘤(AMF)是一种罕见的良性软组织肿瘤,主要发生在中年妇女的外阴阴道区域。将 AMF 与其他间质细胞病变区分开来具有重要的临床意义。在此,我们报告了一例罕见的巨大盆腔 AMF 患者,其表现为良性临床过程。肿瘤位于道格拉斯窝。边界清楚,细胞稀少,水肿,由围绕薄壁血管聚集的梭形和椭圆形基质细胞组成。肿瘤细胞具有丰富的嗜酸性细胞质,并表达雌激素受体、孕激素受体和结蛋白。无有丝分裂象。区分 AMF 和侵袭性血管黏液瘤很重要,因为两者发生在相似的部位,但表现出不同的临床行为。大多数 AMF 和侵袭性血管黏液瘤具有相同的免疫组化表型。AMF 的边界清楚是将其与侵袭性血管黏液瘤区分开来的最重要特征。AMF 在完全手术切除后很少复发。

虚拟幻灯片

本文的虚拟幻灯片可在此处找到:http://www.diagnosticpathology.diagnomx.eu/vs/5510813471244189.

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11e/4066829/768b2ff6318a/1746-1596-9-106-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11e/4066829/4d757b1b38d4/1746-1596-9-106-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11e/4066829/b87d867605ae/1746-1596-9-106-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11e/4066829/768b2ff6318a/1746-1596-9-106-3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11e/4066829/4d757b1b38d4/1746-1596-9-106-1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11e/4066829/b87d867605ae/1746-1596-9-106-2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a11e/4066829/768b2ff6318a/1746-1596-9-106-3.jpg

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