Kedziora-Kornatowska Kornelia, Kujawski Krzysztof, Błaszczak Robert, Rysz Jacek, Markuszewsk Leszek, Koter Maria, Duchnowicz Piotr, Kornatowski Tomasz, Olszewski Robert, Kedziora Józef
Uniwersytet Medyczny w Toruniu, Collegium Medicum w Bydgoszczy, Katedra i Klinika Geriatrii.
Pol Merkur Lekarski. 2006 Jan;20(115):57-61.
The free radical theory of aging assumes that aging process leads to lost of oxidative balance. Oxidative stress induces structural and functional changes in red blood cell. The Q10 coenzyme is known as a compound which may partially prevent those changes in erythrocytes, due to its antioxidative properties and the important role it plays in the cell. The content of the coenzyme in human body decreases with age. The aim of the research was to evaluate the degree of membrane lipid peroxidation, internal microviscosity, activity of membrane ATP-ase and oxidative damage markers of erythrocyte membrane protein in elderly people before and after Q10 coenzyme therapy.
The examination was performed on 35 people. The examined group consisted of elderly people (older than 65 years old). The reference group was formed with people at the age between 51 and 59. In both groups the initial parameters of red blood cells were evaluated. In the elderly people the investigated parameters were also controlled after three and six weeks of Q10 coenzyme intake.
The Q10 coenzyme supplementation in elderly people produced the increase in the -SH group contents and reduction of W/S parameter. After supplementation of Q 10 coenzyme the decrease of lipid peroxidation products and internal microviscosity of erythrocytes and increase of the activity of membrane ATP-ase (total and Na+,K+) were observed.
The obtained results may indicate the intensification of oxidative stress in elderly and point to beneficial effect of supplementation-metabolic therapy with Q10 coenzyme on structural and functional parameters of red blood cells in elderly people.
衰老的自由基理论认为，衰老过程会导致氧化平衡的丧失。氧化应激会诱导红细胞发生结构和功能变化。辅酶Q10是一种因其抗氧化特性及其在细胞中发挥的重要作用而可能部分预防红细胞发生这些变化的化合物。人体内辅酶的含量会随着年龄的增长而降低。本研究的目的是评估辅酶Q10治疗前后老年人红细胞膜脂质过氧化程度、内部微粘度、膜ATP酶活性以及红细胞膜蛋白氧化损伤标志物。
对35人进行了检查。受检组由老年人（65岁以上）组成。参照组由年龄在51至59岁之间的人组成。对两组的红细胞初始参数进行了评估。在老年人中，在摄入辅酶Q10三周和六周后也对研究参数进行了控制。
老年人补充辅酶Q10后，-SH基团含量增加，W/S参数降低。补充辅酶Q10后，观察到脂质过氧化产物减少、红细胞内部微粘度降低以及膜ATP酶（总活性及Na+、K+活性）活性增加。
所获得的结果可能表明老年人氧化应激加剧，并表明辅酶Q10补充代谢疗法对老年人红细胞的结构和功能参数具有有益作用。
