Kedziora-Kornatowska Kornelia, Kujawski Krzysztof, Błaszczak Robert, Rysz Jacek, Markuszewski Leszek, Koter Maria, Duchnowicz Piotr, Kornatowski Tomasz, Olszewski Robert, Kedziora Józef
Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra i Klinika Geriatrii.
Pol Merkur Lekarski. 2006 Jun;20(120):646-50.
The aim of the study was to evaluate the degree of membrane lipid peroxidation, internal microviscosity, activity of both total and Na+, K+ membrane ATP-ase and markers of oxidative damage of membrane protein in erythrocytes of elderly people with primary hypertension.
The examination was performed on 50 people. The first group (HA) consisted of 15 elderly people with primary hypertension (mean age 71, 3 years old). The reference groups were formed with healthy elderly people (K1) (15 people, mean age 72, 4 years old) and younger healthy people (K2) (20 people, mean age 55, 3 years old).
Membrane lipid peroxidation of red blood cells was significantly increased in the group of elderly people with primary hypertension (HA). The lowest level of lipid peroxidation was observed in the (K2) normotensive group of younger people. Erythrocyte internal microviscosity was significantly higher in the group of healthy elderly people (K1) compared with the group of healthy younger people (K2). In HA group additional essential increase in microviscosity was observed in comparison with K1 and K2. The activity of both total and Na+, K+ membrane ATP-ase was significantly the highest in the group of younger people and the lowest in the group of elderly people with primary hypertension. In HA group increased damage of membrane protein was observed that was indicated by the reduced -SH group content and the increased value of W/S parameter in comparison with K1 and K2 groups.
The obtained results indicate that in the elderly people with accompanying primary hypertension the whole-body oxidative stress is increased, which may be indicated by structural and functional oxidative damage of red blood cells. These observations may be significant in the pathogenesis of hypertension complications. This observation may be important in the pathogenesis of hypertension complications in this period of life.
本研究的目的是评估原发性高血压老年患者红细胞膜脂质过氧化程度、内部微粘度、总膜ATP酶和Na +、K +膜ATP酶活性以及膜蛋白氧化损伤标志物。
对50人进行了检查。第一组（HA）由15名原发性高血压老年人组成（平均年龄71.3岁）。参照组由健康老年人（K1）（15人，平均年龄72.4岁）和年轻健康人（K2）（20人，平均年龄55.3岁）组成。
原发性高血压老年组（HA）红细胞膜脂质过氧化显著增加。在（K2）年轻正常血压组中观察到脂质过氧化水平最低。与年轻健康组（K2）相比，健康老年组（K1）红细胞内部微粘度显著更高。与K1和K2组相比，HA组微粘度进一步显著增加。总膜ATP酶和Na +、K +膜ATP酶活性在年轻组中显著最高，在原发性高血压老年组中最低。与K1和K2组相比，HA组膜蛋白损伤增加，表现为-SH基团含量降低和W/S参数值增加。
所得结果表明，伴有原发性高血压的老年人全身氧化应激增加，这可能由红细胞的结构和功能氧化损伤所表明。这些观察结果在高血压并发症的发病机制中可能具有重要意义。这一观察结果在这一生命阶段高血压并发症的发病机制中可能很重要。
