Hannerz Jan, Dahlgren Gunnar, Irestedt Lars, Meyerson Björn, Ericson Kaj
Department of Neurology, Karolinska Hospital, Stockholm, Sweden.
Headache. 2006 Mar;46(3):508-11. doi: 10.1111/j.1526-4610.2006.00383.x.
Twelve consecutive patients with clinical symptoms and testing results compatible with a diagnosis of idiopathic intracranial hypotension (IIH), but no identifiable site of cerebrospinal fluid (CSF) leakage, were treated with a cervicothoracic or lumbar epidural "blood patch" (EBP) or orally administered steroids.
Prompt and complete relief from headache persisting for at least 4 months was attained in 3 of 4 treatments with cervicothoracic EBP, 2 of 15 with lumbar EBP, and 4 of 8 with steroids.
These results suggest that in patients who presumably suffer from IIH and yet have no identifiable site of CSF leakage, the presumed leakage more often occurs at the cervicothoracic level than the lumbar. In addition, our experience suggests that some IIH patients may be treated effectively with oral steroids and a trial of such therapy may be considered as an alternative to EBP.
连续纳入12例临床症状及检查结果符合特发性颅内低压(IIH)诊断,但无法确定脑脊液(CSF)漏出部位的患者,给予颈胸段或腰段硬膜外“血补丁”(EBP)治疗或口服类固醇激素。
颈胸段EBP治疗4例中有3例、腰段EBP治疗15例中有2例、类固醇激素治疗8例中有4例,持续至少4个月的头痛迅速完全缓解。
这些结果表明,在推测患有IIH但未发现CSF漏出部位的患者中,推测的漏出更常发生在颈胸段而非腰段。此外,我们的经验表明,一些IIH患者口服类固醇激素治疗可能有效,可考虑将这种治疗试验作为EBP的替代方法。