单糖基、二糖基和二核苷亚甲基二膦酸酯：直接合成及抗病毒活性。
Monoglycosyl, diglycosyl, and dinucleoside methylenediphosphonates: direct synthesis and antiviral activity.
作者信息
Grison Claude, Joliez Stéphane, De Clercq E, Coutrot Philippe
机构信息
Laboratoire de Chimie Biomoléculaire, UMR CNRS 7565, Institut Nancéien de Chimie Moléculaire, Université Henri Poincaré, Nancy 1, BP 239, F-54506 Vandoeuvre-lès-Nancy, France.
出版信息
Carbohydr Res. 2006 Jul 3;341(9):1117-29. doi: 10.1016/j.carres.2006.03.023. Epub 2006 Apr 18.
A direct and general access to D-glycosyl 3-, 5-, or 6-methylenediphosphonates, di-D-glycosyl 1,5-, 3,5-, 3,6-, 5,5-, or 6,6-methylenediphosphonates and dithymidine 3',5'-methylenediphosphonate is described. The method involves the one-pot alkylidenediphosphorylation of glycosyl or thymidine derivatives. No antiviral activity was detected against a panel of RNA and DNA viruses.
描述了一种直接且通用的方法来制备D-糖基3-、5-或6-亚甲基二膦酸酯、二-D-糖基1,5-、3,5-、3,6-、5,5-或6,6-亚甲基二膦酸酯以及二胸苷3',5'-亚甲基二膦酸酯。该方法涉及糖基或胸苷衍生物的一锅法亚烷基二磷酸化反应。针对一组RNA和DNA病毒未检测到抗病毒活性。
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