Adriaan Bouwknecht J, Olivier Berend, Paylor Richard E
Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.
Neurosci Biobehav Rev. 2007;31(1):41-59. doi: 10.1016/j.neubiorev.2006.02.002. Epub 2006 Apr 17.
This paper reviews the function, brain mechanisms and pharmacology of stress-induced hyperthermia (SIH) in a broad context. Hyperthermia itself is induced by all stressful stimuli and can be found across numerous species, including humans. As a model for anxiety, the process of insertion of a rectal probe increases temperature ranging from about 0.5-1.5 degrees C in 10-15min is called SIH. This temperature increase can be blocked by anxiolytic drugs. The methodological as well as pharmacological aspects of the group- (G-SIH) and singly housed (SIH) version of the paradigm are described in detail. Also, an overview is presented about studies using the SIH procedure in genetically modified mice together with the potential interference with immunological induction of a febrile response. The paper also presents data that highlight some of the limitations of the SIH procedure for use of drugs like nicotine, which contain particular characteristics such as short in vivo half-life, and/or disturbance of thermoregulation. The advantages and disadvantages of the SIH procedure as a physiological model of anxiety are discussed.
本文在广泛的背景下综述了应激诱导性体温过高（SIH）的功能、脑机制和药理学。体温过高本身由所有应激刺激诱发，在包括人类在内的众多物种中都能发现。作为一种焦虑模型，插入直肠探头的过程会使体温在10 - 15分钟内升高约0.5 - 1.5摄氏度，这一过程被称为SIH。这种体温升高可被抗焦虑药物阻断。文中详细描述了该范式的成组饲养（G - SIH）和单笼饲养（SIH）版本的方法学及药理学方面。此外，还概述了在转基因小鼠中使用SIH程序的研究，以及其对发热反应免疫诱导的潜在干扰。本文还展示了一些数据，这些数据突出了SIH程序在使用尼古丁等药物时的一些局限性，尼古丁具有体内半衰期短和/或体温调节紊乱等特殊特征。文中讨论了SIH程序作为焦虑生理模型的优缺点。
