Wang Yen-Pin, Young Yi-Ho
Department of Otolaryngology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan.
Acta Otolaryngol. 2006 Mar;126(3):271-6. doi: 10.1080/00016480500388984.
Excluding the possibility of acoustic neuroma, therapeutic benefits from dextran 40 can be anticipated in a pregnant woman with sudden deafness, leading to significant hearing improvement, without detrimental effect on the mother or fetus.
The aim of this study was to present our experience in the treatment of pregnant women with sudden deafness during the past decade.
From January 1994 to December 2003, 12 pregnant women with sudden deafness were consecutively encountered at the authors' clinic. With the exception of one patient with acoustic neuroma who underwent craniotomy, six patients were treated with dextran 40 only, while the other five patients preferred no medication, and served as a control group. Each patient underwent audiometry before treatment and at 1 year postpartum.
In the dextran group, five (83%) of six patients had hearing improvement 1 year postpartum, compared with one (20%) of five patients in the control group showing hearing improvement; both groups revealed a significant difference. Those receiving intravenous dextran treatment had significant hearing improvement at the frequencies of 1000, 2000, and 4000 Hz, at 1 year postpartum. In contrast, in those who followed a natural course without medication no significant difference existed in the mean hearing level of each frequency, at 1 year after delivery.
排除听神经瘤的可能性，对于患有突发性耳聋的孕妇，可预期右旋糖酐40具有治疗益处，能显著改善听力，且对母亲和胎儿均无不良影响。
本研究的目的是介绍我们在过去十年中治疗突发性耳聋孕妇的经验。
从1994年1月至2003年12月，作者所在诊所连续接诊了12例突发性耳聋孕妇。除1例接受开颅手术的听神经瘤患者外，6例患者仅接受右旋糖酐40治疗，另外5例患者未用药，作为对照组。每位患者在治疗前及产后1年均接受听力测定。
在右旋糖酐组中，6例患者中有5例（83%）产后1年听力得到改善，而对照组5例患者中有1例（20%）听力改善；两组间差异显著。接受静脉右旋糖酐治疗的患者在产后1年时，1000、2000和4000赫兹频率的听力有显著改善。相比之下，未用药而自然恢复的患者在产后1年时，各频率的平均听力水平无显著差异。
