Department of Otolaryngology, Nantong Hospital of Traditional Chinese Medicine, Nantong Hospital Affiliated to Nanjing University of Chinese Medicine, Nantong, Jiangsu, China.
J Int Adv Otol. 2024 Sep 26;20(5):431-438. doi: 10.5152/iao.2024.241601.
Patients with sudden sensorineural hearing loss (SSNHL) may lose their hearing. The relationship between SSNHL and total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels is still unclear. The association of TC, TG, HDL-C, and LDL-C levels with the risk and prognosis of SSNHL was explored in this study. After searching for literature in different databases, 13 researches were used to summarize the risk and prognosis of SSNHL associations with TC, TG, HDL-C, and LDL-C using meta-analysis. Total cholesterol had a significant association with the risk of SSNHL (95% CI, 1.34-2.91). Adjustment for confounding factors and grouping criteria of TG were all significant sources of heterogeneity. One of the significant sources of heterogeneity in the LDL-C subgroup analyses was an adjustment for confounders. Sensitivity analysis revealed a robust association between TC and the risk of SSNHL. There was a significant publication bias in the association between TC and SSNHL prognosis High TC level is a risk factor for SSNHL.
突发性聋（SSNHL）患者可能会丧失听力。SSNHL 与总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）水平之间的关系尚不清楚。本研究旨在探讨 TC、TG、HDL-C 和 LDL-C 水平与 SSNHL 风险和预后的关系。在不同数据库中搜索文献后，使用荟萃分析对 13 项研究进行了总结，以评估 TC、TG、HDL-C 和 LDL-C 与 SSNHL 风险和预后的关系。总胆固醇与 SSNHL 的风险显著相关（95%CI，1.34-2.91）。调整混杂因素和 TG 的分组标准均是异质性的重要来源。在 LDL-C 亚组分析中，混杂因素的调整是一个显著的异质性来源。敏感性分析显示 TC 与 SSNHL 风险之间存在稳健的关联。TC 与 SSNHL 预后之间存在显著的发表偏倚。高 TC 水平是 SSNHL 的一个危险因素。
