Fan Guo-Kang, Xu Fengzhi, Yang Beibei, Fujieda Shigeharu
Department of Otorhinolaryngology, 2nd Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang, People's Republic of China.
Acta Otolaryngol. 2006 Mar;126(3):301-5. doi: 10.1080/00016480500388851.
Reduction of p57(kip2) expression is related to carcinogenesis in laryngeal mucosa. Assessment of p57(kip2) expression may be a promising candidate as a progressive biomarker in laryngeal squamous cell carcinoma (SCC).
To investigate the expression and significance of p57(kip2) in a dysplasia/carcinoma sequence of laryngeal mucosa.
A retrospective study was performed involving 10 cases of normal mucosa, 31 of laryngeal leukoplakia and 109 of laryngeal SCC. p57(kip2) and p53 protein expression was detected in the tissue samples of these patients using immunohistochemistry.
p57(kip2) expression was decreased in leukoplakia with moderate or severe dysplasia, and further decreased in SCC. No significant difference was found between normal mucosa and leukoplakia with no or mild dysplasia. In patients with laryngeal SCC, advanced tumor size and clinical stage and the recurrence of disease were associated with reduced p57(kip2) expression. The occurrence of lymph node metastasis was also related to negative expression of p57(kip2). The overall 5-year disease-free survival rate of patients with laryngeal SCC was significantly higher in the p57(kip2)-positive than in the p57(kip2)-negative group.
p57(kip2)表达降低与喉黏膜癌变相关。评估p57(kip2)表达可能是喉鳞状细胞癌（SCC）中有前景的进展性生物标志物。
探讨p57(kip2)在喉黏膜发育异常/癌变序列中的表达及意义。
进行一项回顾性研究，纳入10例正常黏膜、31例喉白斑和109例喉SCC患者。采用免疫组织化学法检测这些患者组织样本中p57(kip2)和p53蛋白表达。
中重度发育异常的白斑中p57(kip2)表达降低，在SCC中进一步降低。正常黏膜与无或轻度发育异常的白斑之间未发现显著差异。在喉SCC患者中，肿瘤大小、临床分期进展及疾病复发与p57(kip2)表达降低相关。淋巴结转移的发生也与p57(kip2)阴性表达有关。p57(kip2)阳性的喉SCC患者总体5年无病生存率显著高于p57(kip2)阴性组。
