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本文引用的文献

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The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.染色质重塑复合物WSTF-SNF2h与核肌球蛋白1相互作用，并在RNA聚合酶I转录中发挥作用。
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The Sir 2 family of protein deacetylases.蛋白质脱乙酰酶的Sir2家族。
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Genetic inactivation of the transcription factor TIF-IA leads to nucleolar disruption, cell cycle arrest, and p53-mediated apoptosis.转录因子TIF-IA的基因失活会导致核仁破坏、细胞周期停滞以及p53介导的细胞凋亡。
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Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase.小鼠Sir2同源物SIRT6是一种核ADP核糖基转移酶。
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Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.通过PGC-1α和SIRT1复合物对葡萄糖稳态进行营养控制。
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The Sir2 family of protein deacetylases.蛋白质去乙酰化酶的Sir2家族。
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Calorie restriction extends yeast life span by lowering the level of NADH.热量限制通过降低NADH水平来延长酵母的寿命。
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Identification of novel protein-protein interactions using a versatile mammalian tandem affinity purification expression system.使用通用的哺乳动物串联亲和纯化表达系统鉴定新型蛋白质-蛋白质相互作用。
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哺乳动物Sir2同源物SIRT7是RNA聚合酶I转录的激活剂。

Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription.

作者信息

Ford Ethan, Voit Renate, Liszt Gregory, Magin Cornelia, Grummt Ingrid, Guarente Leonard

机构信息

Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.

出版信息

Genes Dev. 2006 May 1;20(9):1075-80. doi: 10.1101/gad.1399706. Epub 2006 Apr 17.

DOI:10.1101/gad.1399706
PMID:16618798
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1472467/
Abstract

We investigated the role of SIRT7, one of the seven members of the mammalian sirtuin family. We show that SIRT7 is a widely expressed nucleolar protein that is associated with active rRNA genes (rDNA), where it interacts with RNA polymerase I (Pol I) as well as with histones. Overexpression of SIRT7 increases Pol I-mediated transcription, whereas knockdown of SIRT7 or inhibition of the catalytic activity results in decreased association of Pol I with rDNA and a reduction of Pol I transcription. Depletion of SIRT7 stops cell proliferation and triggers apoptosis. Our findings suggest that SIRT7 is a positive regulator of Pol I transcription and is required for cell viability in mammals.

摘要

我们研究了哺乳动物沉默调节蛋白家族七个成员之一的SIRT7的作用。我们发现，SIRT7是一种广泛表达的核仁蛋白，与活跃的核糖体RNA基因（rDNA）相关联，在那里它与RNA聚合酶I（Pol I）以及组蛋白相互作用。SIRT7的过表达增加了Pol I介导的转录，而SIRT7的敲低或催化活性的抑制导致Pol I与rDNA的结合减少以及Pol I转录的降低。SIRT7的缺失会阻止细胞增殖并引发凋亡。我们的研究结果表明，SIRT7是Pol I转录的正调节因子，是哺乳动物细胞活力所必需的。