Colfax Grant, Guzman Robert
AIDS Office, HIV/AIDS Statistics, Epidemiology, andIntervention Research Section, San Francisco Department of Public Health, San Francisco, California 94102, USA.
Clin Infect Dis. 2006 May 15;42(10):1463-9. doi: 10.1086/503259. Epub 2006 Mar 31.
Club drug use is common among populations with human immunodeficiency virus (HIV) and populations at high risk for HIV infection. Club drugs have a myriad of acute and chronic medical consequences. Club drug-related visits to the emergency department and admissions for treatment of substance use have increased dramatically over the past 15 years. Most epidemiological data support the role of club drugs in increasing sexual risk behavior, with some studies demonstrating an independent association between use of certain club drugs and HIV infection. The direct influence of club drugs on progression of HIV disease remains to be determined; however, club drugs may interact with certain retroviral medications and have been associated with decreased adherence to medication. Clinicians should ask all patients about patterns of club drug use, counsel patients about the risks associated with club drug use, and refer patients to appropriate behavioral treatment programs for substance use when clinically indicated.
在感染人类免疫缺陷病毒（HIV）的人群以及有感染HIV高风险的人群中，使用俱乐部药物的情况很常见。俱乐部药物会引发众多急性和慢性医学后果。在过去15年里，因俱乐部药物相关问题前往急诊科就诊以及因物质使用问题住院治疗的人数急剧增加。大多数流行病学数据支持俱乐部药物在增加性风险行为方面所起的作用，一些研究表明使用某些俱乐部药物与HIV感染之间存在独立关联。俱乐部药物对HIV疾病进展的直接影响仍有待确定；然而，俱乐部药物可能与某些抗逆转录病毒药物相互作用，并与用药依从性降低有关。临床医生应询问所有患者使用俱乐部药物的模式，向患者提供有关使用俱乐部药物相关风险的咨询，并在临床指征明确时，将患者转介至适当的物质使用行为治疗项目。
