Prohaska Sonja J, Stadler Peter F
Bioinformatics Group, Department of Computer Science, and Interdisciplinary Center for Bioinformatics, University of Leipzig, D-04107 Leipzig, Germany.
J Exp Zool B Mol Dev Evol. 2006 Sep 15;306(5):481-7. doi: 10.1002/jez.b.21099.
The ParaHox cluster contains three Hox-related homeobox genes. The evolution of this sister of the Hox-gene clusters has been studied extensively in metazoans with a focus on its early evolution. Its fate within the vertebrate lineage, and in particular following the teleost-specific genome duplication, however, has not received much attention. Three of the four human ParaHox loci are linked with PDGFR family tyrosine kinases. We demonstrate that these loci arose as duplications in an ancestral vertebrate and trace the subsequent history of gene losses. Surprisingly, teleost fishes have not expanded their ParaHox repertoire following the teleost-specific genome duplication, while duplicates of the associated tyrosine kinases have survived, supporting the hypothesis of a large-scale duplication followed by extensive gene loss.
副同源框基因簇包含三个与同源框基因相关的同源异型框基因。后生动物中对这个同源框基因簇姐妹群的进化进行了广泛研究，重点是其早期进化。然而，它在脊椎动物谱系中的命运，特别是在硬骨鱼特异性基因组复制之后，并未受到太多关注。四个人类副同源框基因座中的三个与血小板衍生生长因子受体（PDGFR）家族酪氨酸激酶相关。我们证明这些基因座是在一个远古脊椎动物中通过复制产生的，并追溯了随后的基因丢失历史。令人惊讶的是，硬骨鱼在硬骨鱼特异性基因组复制后并未扩展其副同源框基因库，而相关酪氨酸激酶的复制基因却得以保留，这支持了大规模复制后伴随广泛基因丢失的假说。
