作为脊椎动物基因组进化模型的Hox基因簇

Hox clusters as models for vertebrate genome evolution.

作者信息

Hoegg Simone, Meyer Axel

机构信息

Lehrstuhl für Zoologie und Evolutionsbiologie, Department of Biology, University of Konstanz, 78457 Konstanz, Germany.

出版信息

Trends Genet. 2005 Aug;21(8):421-4. doi: 10.1016/j.tig.2005.06.004.

DOI:10.1016/j.tig.2005.06.004

PMID:15967537

Abstract

The surprising variation in the number of Hox clusters and the genomic architecture within vertebrate lineages, especially within the ray-finned fish, reflects a history of duplications and subsequent lineage-specific gene loss. Recent research on the evolution of conserved non-coding sequences (CNS) in Hox clusters promises to reveal interesting results for functional and phenotypic diversification.

摘要

脊椎动物谱系中，尤其是硬骨鱼纲内，Hox基因簇数量和基因组结构存在惊人的差异，这反映了基因重复以及随后特定谱系基因丢失的历史。近期关于Hox基因簇中保守非编码序列（CNS）进化的研究有望揭示功能和表型多样化方面的有趣结果。