Sharma Rajnikant, Negi Devendra S, Shiu Winnie K P, Gibbons Simon
Department of Chemistry, PO Box No 75, HNB Garwhal University, Srinagar (Garhwal), Uttaranchal - 246 174, India.
Phytother Res. 2006 Jul;20(7):607-9. doi: 10.1002/ptr.1909.
The leaves of Boenninghausenia albiflora afforded an insecticidal coumarin which was identified as murraxocin (7-methoxy-8-[1'-ethoxy-2'-hydroxy-3'-methyl-but-3'enyl]-coumarin) (1), on the basis of extensive 1- and 2-dimensional NMR experiments. This compound has previously been isolated from Murraya exotica but this is the first report of the full (1)H and (13)C data for this compound. This natural product was evaluated against important forest insect pests and was active against Plecoptera reflexa, Clostera cupreata and Crypsiptya coclesalis at different concentrations varying from 1.0% to 5% w/v. In the crude extract 70% mortality was observed, and for compound 1 80% mortality was observed at a concentration of 1.0% w/v. The percentage of insect mortality increased in a dose-dependent manner. Coumarins are poorly studied insecticides and there is potential to exploit this chemically simple group of natural products.
白花石椒草的叶子产生了一种具有杀虫活性的香豆素，基于广泛的一维和二维核磁共振实验，该香豆素被鉴定为murraxocin（7-甲氧基-8-[1'-乙氧基-2'-羟基-3'-甲基-丁-3'-烯基]-香豆素）（1）。该化合物先前已从九里香中分离得到，但这是关于该化合物完整的氢谱和碳谱数据的首次报道。对这种天然产物针对重要森林害虫进行了评估，在1.0%至5%w/v的不同浓度下，对扁襀、铜绿尺蛾和隐纹谷弄蝶具有活性。在粗提物中观察到70%的死亡率，对于化合物1，在浓度为1.0%w/v时观察到80%的死亡率。昆虫死亡率百分比呈剂量依赖性增加。香豆素类杀虫剂的研究较少，开发这类化学结构简单的天然产物具有潜力。
