Lo Muzio Lorenzo, Campisi Giuseppina, Farina Antonio, Rubini Corrado, Ferrari Francesca, Falaschini Silvia, Leonardi Rosalia, Carinci Francesco, Stalbano Stefania, De Rosa Gaetano
Department of Surgical Sciences, University of Foggia, Foggia, Italy.
Anticancer Res. 2006 Mar-Apr;26(2B):1343-9.
The aims of the present study were to assess the prevalence of HSP27 expression in oral squamous cell carcinoma (OSCC) and to verify whether HSP27 can be considered to be a marker of prognosis in patients with OSCC.
The immunohistochemical expression of HSP27 was evaluated in 57 OSCC, who received standard treatment and monitoring. After grouping for HSP27 expression, OSCCs were statistically analysed for the variables age, gender, histological grading, TNM, staging and survival rate. Univariate and multivariate analyses were performed.
HSP27 was found to be reduced in 31 OSCC and was normally expressed in 26 OSCC. The pattern and intensity of HSP27 immunolabelling did not show significant differences in relation to any variables retrospectively considered. In terms of prognostic significance, HSP27 reduced expression was found to have an independent association with the poorest overall survival rate (p=0.009; OR= 4.404; CI=1.444:13.427 by Cox regression).
HSP27 reduced expression is an early marker of poor prognosis, useful in identifying aggressive biological behaviour in OSCC cases even before relapse.
本研究的目的是评估热休克蛋白27（HSP27）在口腔鳞状细胞癌（OSCC）中的表达率，并验证HSP27是否可被视为OSCC患者的预后标志物。
对57例接受标准治疗和监测的OSCC患者进行HSP27免疫组化表达评估。根据HSP27表达分组后，对OSCC患者的年龄、性别、组织学分级、TNM分期和生存率等变量进行统计学分析。进行单因素和多因素分析。
发现31例OSCC患者HSP27表达降低，26例OSCC患者HSP27正常表达。回顾性分析发现，HSP27免疫标记的模式和强度与任何变量均无显著差异。就预后意义而言，发现HSP27表达降低与最差的总生存率独立相关（通过Cox回归分析，p = 0.009；OR = 4.404；CI = 1.444:13.427）。
HSP27表达降低是预后不良的早期标志物，有助于在OSCC病例复发前识别侵袭性生物学行为。
