Brelén Mårten E, De Potter Patrick, Gersdorff Michel, Cosnard Guy, Veraart Claude, Delbeke Jean
Neural Rehabilitation Engineering Laboratory, Université Catholique de Louvain, Brussels, Belgium.
J Neurosurg. 2006 Apr;104(4):593-7. doi: 10.3171/jns.2006.104.4.593.
Research into visual prosthetics is expected to revolutionize the treatment of blind patients with incurable outer retinal degenerative disease. Substantial evidence shows that useful visual sensations can be produced by controlled electrical stimulation of the optic nerve. To make the optic nerve visual prosthesis more acceptable, implantation techniques safer and less invasive than those previously used have been developed. A medial transconjunctival approach is now used to implant a stimulating electrode around the intraorbital section of the optic nerve. This new technique allows sufficient exposure of the nerve after detaching only one rectus muscle and performing a lateral canthotomy. Previously, an electrode was implanted in the intracranial part of the optic nerve, which required more invasive surgery. The new technique was first developed in cadavers and in patients undergoing eye enucleations. Finally, a 68-year-old blind man suffering from retinitis pigmentosa underwent long-term implantation. In this case report the authors describe the technique and outline some of the challenges involved.
视觉假体的研究有望彻底改变不可治愈的外层视网膜退行性疾病导致的盲人患者的治疗方式。大量证据表明,通过对视神经进行可控电刺激能够产生有用的视觉感受。为了使视神经视觉假体更容易被接受,现已开发出比以前使用的技术更安全、侵入性更小的植入技术。目前采用经结膜内侧入路在眶内段视神经周围植入刺激电极。这种新技术仅在分离一条直肌并进行外眦切开术后就能充分暴露神经。以前,电极是植入视神经的颅内部分,这需要更具侵入性的手术。这项新技术最初是在尸体和接受眼球摘除术的患者身上开发的。最后,一名患有色素性视网膜炎的68岁盲人男性接受了长期植入。在本病例报告中,作者描述了该技术并概述了其中涉及的一些挑战。