Wang Victor, Kuriyan Ajay E
University of Rochester School of Medicine and Dentistry, Rochester, NY, USA.
Retina Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, PA, USA.
Curr Ophthalmol Rep. 2020 Jun;8(2):69-77. doi: 10.1007/s40135-020-00232-2. Epub 2020 Apr 20.
The goal is providing an update to the latest research surrounding optoelectronic devices, highlighting key studies and benefits and limitations of each device.
The Argus II demonstrated long-term safety after five-year follow-up. Due to lack of tack fixation, subretinal implants appear to displace over time. PRIMA's completed primate trial showed initial safety and potential for improved vision, resulting in ongoing clinical trials Bionic Vision Australia developed a new 44-electrode suprachoroidal device currently in a clinical trial. Orion (cortical stimulation) is currently undergoing a clinical trial to demonstrate safety.
Devices using external camera for images are unaffected by corneal or lens opacities but disconnect eye movements from image perception, while the opposite is true for implants directly detecting light. Visual acuity provided by devices is more complicated than implant electrode density and new devices aim to target this with innovative approaches.
目的是更新围绕光电器件的最新研究，突出关键研究以及每种器件的优点和局限性。
阿格斯二代在五年随访后显示出长期安全性。由于缺乏固定，视网膜下植入物似乎会随时间移位。PRIMA完成的灵长类动物试验显示了初步安全性和视力改善潜力，从而促成了正在进行的临床试验。澳大利亚仿生视觉公司开发了一种新型44电极脉络膜上腔装置，目前正在进行临床试验。猎户座（皮层刺激）目前正在进行一项临床试验以证明其安全性。
使用外部摄像头获取图像的器件不受角膜或晶状体混浊的影响，但会使眼球运动与图像感知脱节，而直接检测光的植入物则相反。器件提供的视力比植入电极密度更复杂，新器件旨在通过创新方法解决这一问题。
