[The effect of various doses of ascorbic acid on the development of pneumofibrosis, caused by silicon dioxide].

Long-term administration of ascorbic acid into rats with silicosis retarded lung fibrosis development. Noticeable effect exhibited daily administration of the vitamin in high doses (10 mg per a rat or 40 mg/kg of body mass) which caused statistically distinct decrease in the pneumofibrosis process both within early steps of silicosis (3-6 weeks) and during the developed pneumofibrosis (14 weeks).