Gulumian M
National Centre for Occupational Health and Department of Medical Biochemistry, Johannesburg, South Africa.
Mol Cell Biochem. 1999 Jun;196(1-2):69-77.
Inhalation of silica and asbestos fibres by humans can lead to fibrosis of the lung and cancer. Different mechanistic approaches, including oxidative stress, are used for prophylactic and therapeutic interventions to attenuate the fibrogenic and carcinogenic effects of these particles. Thus far, most of these therapeutic interventions have been only partly successful. A review of the mechanisms which are thought to be involved in mineral particle-induced toxicity and the relevant therapeutic interventions used to date to counteract these mechanisms, will help formulate better prophylactic and treatment intervention strategies in the future.
人类吸入二氧化硅和石棉纤维会导致肺纤维化和癌症。包括氧化应激在内的不同作用机制已被用于预防性和治疗性干预措施，以减轻这些颗粒的致纤维化和致癌作用。到目前为止，这些治疗性干预措施大多只取得了部分成功。综述被认为与矿物颗粒诱导的毒性相关的机制以及迄今为止用于对抗这些机制的相关治疗性干预措施，将有助于在未来制定更好的预防和治疗干预策略。
