Kabukcuoglu S, Oner U, Ozalp S S, Bildirici K, Yalcin O T, Colak E
Department of Pathology, University of Osmangazi School of Medicine, Eskisehir, Turkey.
Eur J Gynaecol Oncol. 2006;27(2):171-6.
The aim of the study was to investigate the role of fascin in tumor progression and to investigate the role of fascin on endothelial cell migration and angiogenesis in ovarian neoplasms.
In the study, 94 malign epithelial ovarian neoplasms, 13 borderline epithelial ovarian neoplasms, 25 serous and mucinous cystadenomas and four normal ovarian tissues were examined by means of immunohistochemistry, using monoclonal antihuman fascin antibody, clone IM20.
Total stromal fascin score in cases of borderline and malign epithelial ovarian tumors was significantly higher compared to normal ovaries and benign epithelial ovarian tumors (.000, p < 0.001). There was no statistically significant difference in terms of total epithelial fascin scores of samples between groups (.080, p > 0.05). Presence of vascular invasion (.000, p < 0.001), psammomatous calcifications (.001, p = 0.001), and lymphocytic infiltration (.000, p < 0.001) were significantly higher in malign neoplasms. There was no significant difference in terms of mean microvessel count and homogeneous or heterogeneous fascin expression of microvessels between the benign and malign groups (respectively p = .228 and p = .143).
This study suggests that up-regulation of fascin in tumoral tissue may promote invasion of ovarian carcinoma by cell-matrix adhesion.
本研究旨在探讨fascin在肿瘤进展中的作用，并研究fascin在卵巢肿瘤中对内皮细胞迁移和血管生成的作用。
在本研究中，采用单克隆抗人fascin抗体（克隆IM20），通过免疫组织化学方法检测了94例恶性上皮性卵巢肿瘤、13例交界性上皮性卵巢肿瘤、25例浆液性和黏液性囊腺瘤以及4例正常卵巢组织。
与正常卵巢和良性上皮性卵巢肿瘤相比，交界性和恶性上皮性卵巢肿瘤的总基质fascin评分显著更高（.000，p < 0.001）。各组样本的总上皮fascin评分在统计学上无显著差异（.080，p > 0.05）。恶性肿瘤中血管侵犯（.000，p < 0.001）、砂粒体钙化（.001，p = 0.001）和淋巴细胞浸润（.000，p < 0.001）的发生率显著更高。良性和恶性组之间的微血管平均计数以及微血管fascin表达的均匀或不均匀性方面均无显著差异（分别为p =.228和p =.143）。
本研究表明，肿瘤组织中fascin的上调可能通过细胞-基质黏附促进卵巢癌的侵袭。
