窒息后早产胎儿的急性全身并发症：心血管和血流反应的作用。

Acute systemic complications in the preterm fetus after asphyxia: role of cardiovascular and blood flow responses.

Bennet L, Booth L, Malpas S C, Quaedackers J S, Jensen E, Dean J, Gunn A J

Department of Physiology, Faculty of Medicine and Health Sciences, The University of Auckland, Auckland, New Zealand.

Clin Exp Pharmacol Physiol. 2006 Apr;33(4):291-9. doi: 10.1111/j.1440-1681.2006.04364.x.

Abstract

Poor perfusion of the kidneys and gut, and associated functional impairment, are major problems in the first days of life in very preterm infants. These complications can be associated with a substantial mortality and further problems such as reduced kidney growth and chronic renal problems in later childhood. 2. There is very little information, and consequently considerable debate, about how or even whether to improve perfusion of the vital organs of this most vulnerable group of babies. Current treatments simply do not consistently improve babies' perfusion generally or kidney and gut perfusion and function in particular. 3. In this review we critically examine clinical and experimental evidence that suggests that exposure to low oxygen levels before and during birth may be a significant contributor to impaired systemic perfusion, and highlight areas requiring further research. 4. This knowledge is essential to develop and refine ways of improving perfusion of the kidneys and other vital organs in premature babies.

摘要

肾脏和肠道灌注不足以及相关的功能损害是极早产儿出生后最初几天的主要问题。这些并发症可能导致相当高的死亡率以及后续问题，如儿童后期肾脏生长受限和慢性肾脏问题。2. 关于如何改善甚至是否要改善这群最脆弱婴儿重要器官的灌注，几乎没有相关信息，因此引发了大量争论。目前的治疗方法并不能始终如一地普遍改善婴儿的灌注情况，尤其是肾脏和肠道的灌注及功能。3. 在本综述中，我们批判性地审视了临床和实验证据，这些证据表明出生前和出生期间暴露于低氧水平可能是导致全身灌注受损的一个重要因素，并突出了需要进一步研究的领域。4. 这些知识对于开发和完善改善早产儿肾脏及其他重要器官灌注的方法至关重要。