Doyle Lex W
The Royal Women's Hospital, University of Melbourne, Murdoch Childrens Research Institute, Melbourne, Australia.
Semin Perinatol. 2008 Feb;32(1):28-34. doi: 10.1053/j.semperi.2007.12.005.
Cardiopulmonary diseases dominate the early days after birth for very preterm babies, but most survive these disorders. However, a minority who survive remain oxygen-dependent for a prolonged period, including after discharge. For the remaining very preterm survivors, cardiopulmonary problems are not major health issues in early childhood, apart from higher rates of hospital readmission for respiratory illnesses in the first few years after the primary hospitalization. However, as they progress through childhood and into adulthood, it is clear that very preterm survivors have reduced lung function, higher blood pressure, and other cardiovascular abnormalities that may lead to adverse cardiopulmonary outcomes much earlier in adult life than would normally be expected. The contribution of these cardiopulmonary problems in early adulthood to morbidity in middle and old ages needs to be determined.
对于极早产儿来说，心肺疾病在出生后的早期阶段占主导地位，但大多数患儿能从这些疾病中存活下来。然而，少数存活下来的患儿在很长一段时间内仍依赖氧气，包括出院后。对于其余存活的极早产儿，除了在首次住院后的头几年因呼吸系统疾病再次入院的比例较高外，心肺问题在幼儿期并非主要健康问题。然而，随着他们成长至儿童期并步入成年期，很明显极早产儿的肺功能下降、血压升高以及出现其他心血管异常情况，这些情况可能导致成年后比正常预期更早出现不良心肺结局。需要确定这些成年早期的心肺问题对中老年发病率的影响。
