Bristol-Gould Sarah, Woodruff Teresa K
Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA.
Theriogenology. 2006 Jul 1;66(1):5-13. doi: 10.1016/j.theriogenology.2006.03.019. Epub 2006 Apr 18.
The dynamic regulation of mammalian folliculogenesis is a key component of the reproductive process. Traditionally, the rodent had been used as a model to study ovarian function and reproductive physiology due to the availability of animals, their relatively short cycle length, high rate of fecundity and short generation interval. We maintain that much basic information can be determined using domestic cat ovaries retrieved from local veterinary clinics following routine spaying, without having the expense of maintaining a colony of laboratory cats. Studies of normal feline reproductive physiology and advances in reproductive technology may be extrapolated for use in endangered non-domestic felids. Increased understanding of feline reproduction will be beneficial to veterinary medicine, and to groups working to control feral cat populations. It is important to examine reproductive mechanisms in alternative animal models as there are a vast number of threatened and endangered species in which we lack the critical reproductive information needed to assist in preserving their long-term survival.
哺乳动物卵泡发生的动态调节是生殖过程的关键组成部分。传统上，由于啮齿动物易于获取、周期相对较短、繁殖率高且世代间隔短，一直被用作研究卵巢功能和生殖生理学的模型。我们认为，利用从当地兽医诊所常规绝育后获取的家猫卵巢，可以确定许多基础信息，而无需花费饲养一群实验猫的成本。对正常猫科动物生殖生理学的研究以及生殖技术的进步，可能会被推广应用于濒危的非家猫科动物。对猫科动物繁殖的更多了解将有益于兽医学以及致力于控制野猫数量的群体。在替代动物模型中研究生殖机制很重要，因为有大量受威胁和濒危物种，我们缺乏协助它们长期生存所需的关键生殖信息。
