一种杀真菌单克隆抗体可预防小鼠侵袭性念珠菌病。
A fungicidal monoclonal antibody protects against murine invasive candidiasis.
作者信息
Sevilla María J, Robledo Beatriz, Rementeria Aitor, Moragues María D, Pontón José
机构信息
Departamento de Inmunología, Microbiología y Parasitología, Facultad de Ciencia y Tecnología, Universidad del País Vasco, Apartado 644, E-48080 Bilbao, Vizcaya, Spain.
出版信息
Infect Immun. 2006 May;74(5):3042-5. doi: 10.1128/IAI.74.5.3042-3045.2006.
Abstract
Mice infected by Candida albicans and treated with monoclonal antibody C7 survived longer than saline-treated animals. A prozone-like effect was observed. The in vitro candidacidal activity of macrophages was strongly enhanced when C. albicans was opsonized by C7 and complete murine serum was present.
摘要
感染白色念珠菌并用单克隆抗体C7治疗的小鼠比用生理盐水治疗的动物存活时间更长。观察到一种前带样效应。当白色念珠菌被C7调理且存在完整的小鼠血清时，巨噬细胞的体外杀念珠菌活性会显著增强。
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[Invasive fungal infection in immunocompromised patients].免疫功能低下患者的侵袭性真菌感染
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More is not necessarily better: prozone-like effects in passive immunization with IgG.更多并不一定更好：IgG被动免疫中的前带样效应。
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