Hernandez-Pampaloni Miguel, Takalkar Amol, Yu Jian Q, Zhuang Hongming, Alavi Abass
Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Pediatr Radiol. 2006 Jun;36(6):524-31. doi: 10.1007/s00247-006-0152-z. Epub 2006 Apr 19.
We hypothesized that F-18 FDG-PET could be a useful, functional imaging modality for assessing the initial staging, response to therapy and follow-up of children diagnosed with lymphoma.
To assess the role of whole-body F-18 FDG-PET imaging in patients with lymphoma as an initial staging modality and to measure its predictive value for monitoring the response to therapy and disease recurrence compared to CT and clinical follow-up studies.
As part of their routine clinical care, 24 patients with histologically proven lymphoma (18 Hodgkin disease and 6 non-Hodgkin lymphoma) underwent an F-18 FDG-PET and a CT scan. A total of 28 studies were performed and the entire set of scans retrospectively reviewed. Seven studies were performed for initial staging, 12 for monitoring therapy response and 9 for detecting recurrence. Initial diagnosis was confirmed by histopathology while the gold standard at follow-up was established by clinical follow-up, additional imaging modalities and/or biopsy. F-18 FDG-PET was visually compared to CT on a lesion-by-lesion basis. Fifteen anatomic regions (seven nodal and eight extranodal) were analyzed.
Of the 414 regions analyzed, PET and CT were concordant in 366 (positive in 16 and negative in 350). Discordance was found in 48 regions. Overall sensitivities, specificities, and positive and negative predictive values were 78%, 98%, 94% and 90% for F-18 FDG-PET and 79%, 88%, 90% and 46% for CT, respectively.
F-18 FDG-PET imaging is a useful technique for the staging and follow-up of pediatric patients with lymphoma.
我们推测，F-18 FDG-PET可能是一种用于评估淋巴瘤患儿初始分期、治疗反应及随访的有用的功能成像方法。
评估全身F-18 FDG-PET成像在淋巴瘤患者作为初始分期方法中的作用，并测量其与CT及临床随访研究相比，在监测治疗反应和疾病复发方面的预测价值。
作为常规临床护理的一部分，24例经组织学证实为淋巴瘤的患者（18例霍奇金病和6例非霍奇金淋巴瘤）接受了F-18 FDG-PET和CT扫描。共进行了28项研究，并对整套扫描进行回顾性分析。7项研究用于初始分期，12项用于监测治疗反应，9项用于检测复发。初始诊断通过组织病理学证实，随访时的金标准通过临床随访、其他成像方法和/或活检确定。F-18 FDG-PET与CT在逐个病灶的基础上进行视觉比较。分析了15个解剖区域（7个淋巴结区域和8个结外区域）。
在分析的414个区域中，PET和CT在366个区域结果一致（16个为阳性，350个为阴性）。在48个区域发现不一致。F-18 FDG-PET的总体敏感性、特异性、阳性和阴性预测值分别为78%、98%、94%和90%，CT的分别为79%、88%、90%和46%。
F-18 FDG-PET成像是淋巴瘤患儿分期和随访的有用技术。
