Suzuki Tomoyoshi, Toi Masakazu, Saji Shigehira, Horiguchi Kazumi, Aruga Tomoyuki, Suzuki Eiji, Horiguchi Shinichiro, Funata Nobuaki, Karasawa Katsuyuki, Kamata Noriko
Department of Surgery, Tokyo Metropolitan Komagome Hospital, 3-18-22 Honkomagome, Tokyo 113-0025, Japan.
Int J Clin Oncol. 2006 Apr;11(2):108-19. doi: 10.1007/s10147-006-0564-7.
Breast cancer remains a common disease throughout the world. Here we review new knowledge about early breast cancer obtained during the past 5 years. The prognosis of early breast cancer is generally favorable. Especially, ductal carcinoma in situ has been regarded as a non-life-threatening disease. Therefore, early diagnosis and early onset of the treatment has been important. Early age at menarche, late age at first birth, and late age at menopause are related to breast cancer risk. Examination by mammography and ultrasonography is still the most effective means of detection for premenopausal and postmenopausal women, respectively. Additionally, there have been important advances in MRI, sentinel lymph node biopsy, breast-conserving surgery, partial breast irradiation, neoadjuvant systemic therapy, and adjuvant systemic therapy. Another approach to keeping the disease under control is the elucidation of breast cancer's molecular biological features. Assessment of potential molecular targets can lead to early diagnosis and molecular targeted treatment.
乳腺癌在全球范围内仍然是一种常见疾病。在此，我们回顾过去5年中获得的关于早期乳腺癌的新知识。早期乳腺癌的预后通常较好。特别是，原位导管癌一直被视为一种不危及生命的疾病。因此，早期诊断和尽早开始治疗一直很重要。初潮年龄早、首次生育年龄晚和绝经年龄晚与乳腺癌风险相关。乳腺钼靶检查和超声检查分别仍是绝经前和绝经后女性最有效的检测手段。此外，在磁共振成像（MRI）、前哨淋巴结活检、保乳手术、部分乳腺照射、新辅助全身治疗和辅助全身治疗方面都取得了重要进展。控制该疾病的另一种方法是阐明乳腺癌的分子生物学特征。评估潜在的分子靶点可实现早期诊断和分子靶向治疗。
