Lemaître Vincent, D'Armiento Jeanine
Department of Medicine, Division of Molecular Medicine, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
Birth Defects Res C Embryo Today. 2006 Mar;78(1):1-10. doi: 10.1002/bdrc.20065.
Matrix metalloproteinases (MMPs) are key modulators of many biological processes during pathophysiological events, such as skeletal formation, angiogenesis, cellular migration, inflammation, wound healing, coagulation, lung and cardiovascular diseases, arthritis, and cancer. Twenty-four members of the MMP family have been identified in humans, degrading many components of the extracellular matrix, cellular receptors, and cytokines. This review describes the molecular structure, activation and inhibition, and substrate specificity of MMPs, and their biological function in development and disease.
基质金属蛋白酶（MMPs）是病理生理过程中许多生物学过程的关键调节因子，如骨骼形成、血管生成、细胞迁移、炎症、伤口愈合、凝血、肺部和心血管疾病、关节炎以及癌症。在人类中已鉴定出24个MMP家族成员，它们可降解细胞外基质的许多成分、细胞受体和细胞因子。本文综述了MMPs的分子结构、激活与抑制、底物特异性及其在发育和疾病中的生物学功能。
