铁催化亚胺酰氯与格氏试剂的交叉偶联反应。
Iron-catalyzed cross-coupling of imidoyl chlorides with Grignard reagents.
作者信息
Ottesen Lars K, Ek Fredrik, Olsson Roger
机构信息
ACADIA Pharmaceuticals AB, Medeon Science Park S-20512, Malmö, Sweden.
出版信息
Org Lett. 2006 Apr 27;8(9):1771-3. doi: 10.1021/ol0600234.
PMID:16623547
Abstract
[reaction: see text] A general, high yielding rapid iron-catalyzed cross-coupling reaction between Grignard reagents and imidoyl chlorides is described. These reactions are typically completed within 5 min, resulting in high yields of 71-96% using 5% iron catalyst in a THF-NMP solvent mixture. Functionalized imidoyl chlorides (e.g., R = CO(2)Me) gave excellent yields (89%).
摘要
[反应：见正文] 描述了一种通用的、高产率的格氏试剂与亚胺酰氯之间的快速铁催化交叉偶联反应。这些反应通常在5分钟内完成，在四氢呋喃- N-甲基吡咯烷酮溶剂混合物中使用5%的铁催化剂时，产率高达71-96%。功能化的亚胺酰氯（例如，R = CO₂Me）给出了优异的产率（89%）。
Zotero 插件