铁催化下烯醇磷酸酯与格氏试剂偶联高效制备末端共轭二烯
Efficient preparation of terminal conjugated dienes by coupling of dienol phosphates with grignard reagents under iron catalysis.
作者信息
Cahiez Gérard, Habiak Vanessa, Gager Olivier
机构信息
Laboratoire de Synthèse Organique Sélective et de Chimie Organométallique (SOSCO), UMR 8123 CNRS-UCP-ESCOM, 5, Mail Gay-Lussac, Neuville sur Oise, Cergy-Pontoise Cedex, France.
出版信息
Org Lett. 2008 Jun 19;10(12):2389-92. doi: 10.1021/ol800816f. Epub 2008 May 14.
PMID:18476715
Abstract
An efficient new route to prepare stereoselectively terminal conjugated dienes by coupling Grignard reagents and dienol phosphates in the presence of Fe(acac)3 is described. The synthetic utility of this new iron-catalyzed procedure is illustrated by the synthesis of the pheromone of Diparopsis castanea according to a very expeditious strategy.
摘要
描述了一种在Fe(acac)₃存在下通过格氏试剂与烯醇磷酸酯偶联来立体选择性制备末端共轭二烯的有效新方法。根据一种非常快捷的策略合成栗色木蠹蛾信息素，说明了这种新的铁催化方法的合成实用性。
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