吡咯烷基肽核酸与DNA的杂交：选择性、碱基配对特异性及结合方向。
Hybridization of pyrrolidinyl peptide nucleic acids and DNA: selectivity, base-pairing specificity, and direction of binding.
作者信息
Vilaivan Tirayut, Srisuwannaket Choladda
机构信息
Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand.
出版信息
Org Lett. 2006 Apr 27;8(9):1897-900. doi: 10.1021/ol060448q.
PMID:16623579
Abstract
[structure: see text] A mixed-base, beta-amino acid containing, pyrrolidinyl peptide nucleic acid (PNA) binds strongly and selectively to complementary DNA in an exclusively antiparallel fashion. The PNA-DNA binding specificity strictly follows the Watson-Crick base-pairing rules.
摘要
[结构：见正文] 一种含β-氨基酸的混合碱基吡咯烷基肽核酸（PNA）以完全反平行的方式与互补DNA紧密且选择性地结合。PNA与DNA的结合特异性严格遵循沃森-克里克碱基配对规则。
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