Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand.
Org Lett. 2012 Mar 16;14(6):1440-3. doi: 10.1021/ol300190u. Epub 2012 Feb 29.
The effect of ring size of four- to six-membered cyclic β-amino acid on the hybridization properties of pyrrolidinyl peptide nucleic acid with an alternating α/β peptide backbone is reported. The cyclobutane derivatives (acbcPNA) show the highest T(m) and excellent specificity with cDNA and RNA.
报道了四至六元环β-氨基酸的环大小对具有交替α/β肽主链的吡咯烷嘧啶核酸的杂交性质的影响。环丁烷衍生物（acbcPNA）具有最高的 Tm 和与 cDNA 和 RNA 的优异特异性。
