吡咯烷酮多肽核酸类似物：环大小对杂交性质的影响。
Pyrrolidinyl peptide nucleic acid homologues: effect of ring size on hybridization properties.
机构信息
Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand.
出版信息
Org Lett. 2012 Mar 16;14(6):1440-3. doi: 10.1021/ol300190u. Epub 2012 Feb 29.
PMID:22375845
Abstract
The effect of ring size of four- to six-membered cyclic β-amino acid on the hybridization properties of pyrrolidinyl peptide nucleic acid with an alternating α/β peptide backbone is reported. The cyclobutane derivatives (acbcPNA) show the highest T(m) and excellent specificity with cDNA and RNA.
摘要
报道了四至六元环β-氨基酸的环大小对具有交替α/β肽主链的吡咯烷嘧啶核酸的杂交性质的影响。环丁烷衍生物（acbcPNA）具有最高的 Tm 和与 cDNA 和 RNA 的优异特异性。
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