Ramis I, Catafau J R, Serra J, Bulbena O, Picado C, Gelpi E
Department of Neurochemistry (Eicosanoid Branch), Centro de Investigacion y Desarrollo, CSIC, Barcelona, Spain.
Prostaglandins. 1991 Nov;42(5):411-20. doi: 10.1016/0090-6980(91)90032-b.
The purpose of this study is to examine the "in vivo" release of 15-HETE and other arachidonic acid metabolites in nasal secretions following a challenge with "Dermatophagoides Pteronyssinus" in patients with allergic rhinitis and non-allergic controls. In addition, we examine the effects of a membrane stabilizer, such as sodium cromoglycate, on these metabolites. Thirteen allergic subjects and seven healthy controls are studied. 15-HETE, peptide leukotrienes, LTB4, PGD2, PGE2 and PGF2 alpha levels are evaluated before and after nasal challenge in sodium cromoglycate treated and untreated subjects. This study provides "in vivo" evidence that the pathophysiological responses to nasal antigen challenge could be related to the release of 15-HETE as well as other arachidonic acid metabolites, mainly arising from the lipoxygenase pathway.
本研究的目的是检测变应性鼻炎患者和非变应性对照者在受到“屋尘螨”攻击后鼻分泌物中15-羟二十碳四烯酸（15-HETE）及其他花生四烯酸代谢产物的“体内”释放情况。此外，我们还检测了一种膜稳定剂，如色甘酸钠，对这些代谢产物的影响。研究了13名变应性受试者和7名健康对照者。在色甘酸钠治疗组和未治疗组的受试者中，评估了鼻激发前后15-HETE、肽白三烯、白三烯B4（LTB4）、前列腺素D2（PGD2）、前列腺素E2（PGE2）和前列腺素F2α水平。本研究提供了“体内”证据，表明对鼻抗原激发的病理生理反应可能与15-HETE以及其他主要源自脂氧合酶途径的花生四烯酸代谢产物的释放有关。
