Milatovich A, Song K, Heller R A, Francke U
Department of Genetics, Stanford University School of Medicine, California 94305.
Somat Cell Mol Genet. 1991 Sep;17(5):519-23. doi: 10.1007/BF01233176.
Tumor necrosis factor, TNF, is a 17-kDa protein secreted by macrophages and classified as a cytokine. TNF binds to high-affinity receptors on the cell surface and is involved in a wide variety of biological responses. There are at least two types of receptors, tumor necrosis factor receptors 1 and 2 (TNFR1 and TNFR2). The genes for TNFR1 a 55-kDa protein, and TNFR2, a 70-kDa protein, have been mapped to human chromosomes 1 12 (12pter-cen) and (1pter-p32), respectively, by Southern blot analysis of human x Chinese hamster somatic cell hybrid panels. Recently, the corresponding genes in the mouse have been mapped to chromosomes 4 and 6 in regions that are conserved on human chromosomes 1 and 12.
肿瘤坏死因子（TNF）是一种由巨噬细胞分泌的17千道尔顿蛋白质，属于细胞因子。TNF与细胞表面的高亲和力受体结合，并参与多种生物学反应。至少有两种类型的受体，即肿瘤坏死因子受体1和2（TNFR1和TNFR2）。通过对人×中国仓鼠体细胞杂交面板的Southern印迹分析，已将编码55千道尔顿蛋白质的TNFR1基因和编码70千道尔顿蛋白质的TNFR2基因分别定位到人类染色体1（12pter-cen）和1（1pter-p32）上。最近，小鼠中的相应基因已定位到染色体4和6上与人类染色体1和12保守区域相对应的区域。
