利用多态性串联重复序列将白细胞介素5受体基因定位于人类染色体3 p25 - p26以及小鼠染色体6上靠近Raf - 1基因座的位置。
Mapping of the interleukin 5 receptor gene to human chromosome 3 p25-p26 and to mouse chromosome 6 close to the Raf-1 locus with polymorphic tandem repeat sequences.
作者信息
Jacob C O, Mykytyn K, Varcony T, Drabkin H A
机构信息
Syntex Research R7-201, Palo Alto, California 94304.
出版信息
Mamm Genome. 1993;4(8):435-9. doi: 10.1007/BF00296817.
Simple-sequence tandem repeat sequences in the 3' UTR of interleukin 5 (IL5)-receptor gene of human and mouse are polymorphic in their length among humans and different strains of mice. In 20 different human Epstein-Barr virus (EBV)-transformed cell lines, six alleles of IL5R could be distinguished. In the mouse, three different alleles are found. With the human-specific IL5R tandem repeat marker in human-rodent somatic cell hybrids, the IL5R gene was mapped to human Chromosome (Chr) 3 p25-p26. With the mouse-specific IL5R tandem repeat sequence in recombinant inbred strains of mice, the Il5r gene was mapped to the distal part of mouse Chr 6 close to the Raf-1 locus.
人类和小鼠白细胞介素5（IL5）受体基因3'非翻译区中的简单序列串联重复序列在人类和不同品系小鼠中的长度具有多态性。在20种不同的人类爱泼斯坦-巴尔病毒（EBV）转化细胞系中，可以区分出IL5R的六个等位基因。在小鼠中，发现了三种不同的等位基因。利用人类-啮齿动物体细胞杂种中的人类特异性IL5R串联重复标记，将IL5R基因定位到人类染色体（Chr）3 p25-p26。利用小鼠重组近交系中的小鼠特异性IL5R串联重复序列，将Il5r基因定位到小鼠Chr 6的远端，靠近Raf-1基因座。
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