对于基线肾功能严重不全的患者，等渗造影剂在心血管导管插入术后能更好地维持短期和长期肾功能。

Iso-osmolar contrast medium better preserves short- and long-term renal function after cardiovascular catheterizations in patients with severe baseline renal insufficiency.

作者信息

Hsieh Yu-Cheng, Liu Tsun-Jui, Liang Kae-Woei, Her Hong-Yun, Lin Wei-Wen, Wang Kuo-Yang, Chen Ying-Tsung, Ting Chih-Tai, Lee Wen-Lieng

出版信息

Int J Cardiol. 2006 Jul 28;111(1):182-4. doi: 10.1016/j.ijcard.2005.11.076. Epub 2006 Apr 19.

DOI:10.1016/j.ijcard.2005.11.076

PMID:16624433

Abstract

BACKGROUND

Iso-osmolar iodixanol was shown to least affect very-short-term renal function. However, its short- and long-term renal effects after cardiovascular catheterizations in severe renal insufficiency remain unknown.

METHODS

Patients undergoing elective cardiovascular catheterizations and having pre-procedural serum creatinine (Scr) > or =2.5 mg/dl were prospectively studied. The results were compared to those of historical controls who received iopromide.

RESULTS

The iodixanol group included 27 patients, aged 73+/-1 years, and the case-matched control group consisted of another 27 patients, aged 71+/-1 years. The baseline Scr were 3.0+/-0.3 and 3.0+/-0.2 mg/dl respectively. Although the Scr at 3 months was similar, the Scr at 6 months was lower in the iodixanol group (2.7+/-0.3 vs 4.2+/-0.5 mg/dl, p = 0.017). The absolute and percentage increments in Scr at 3 months (0.0+/-0.2 vs 0.6+/-0.2 mg/dl, p = 0.014, and 1+/-4% vs 24+/-6%, p = 0.003, respectively) and 6 months (-0.3+/-0.2 vs 1.3+/-0.4 mg/dl, p = 0.001, and -10+/-5% vs 47+/-12%, p < 0.001, respectively) were lower in the iodixanol group.

CONCLUSIONS

Iodixanol better preserves short- and long-term renal outcomes in patients with severe baseline renal insufficiency.

摘要

背景

等渗碘克沙醇对极短期肾功能的影响最小。然而，在严重肾功能不全患者进行心血管导管插入术后，其短期和长期肾脏影响仍不清楚。

方法

对接受择期心血管导管插入术且术前血清肌酐（Scr）≥2.5mg/dl的患者进行前瞻性研究。将结果与接受碘普罗胺的历史对照者的结果进行比较。

结果

碘克沙醇组包括27例患者，年龄73±1岁，病例匹配对照组由另外27例患者组成，年龄71±1岁。基线Scr分别为3.0±0.3和3.0±0.2mg/dl。虽然3个月时的Scr相似，但碘克沙醇组6个月时的Scr较低（2.7±0.3 vs 4.2±0.5mg/dl，p = 0.017）。碘克沙醇组3个月时Scr的绝对增加值和百分比增加值（分别为0.0±0.2 vs 0.6±0.2mg/dl，p = 0.014，以及1±4% vs 24±6%，p = 0.003）和6个月时（-0.3±0.2 vs 1.3±0.4mg/dl，p = 0.001，以及-10±5% vs 47±12%，p < 0.001）均较低。