Federspiel Andrea, Begré Stefan, Kiefer Claus, Schroth Gerhard, Strik Werner K, Dierks Thomas
University Hospital of Clinical Psychiatry, Department of Psychiatric Neurophysiology, Berne, Switzerland.
Neurobiol Dis. 2006 Jun;22(3):702-9. doi: 10.1016/j.nbd.2006.01.015. Epub 2006 Apr 19.
Cerebral disconnectivity due to white matter alterations in patients with chronic schizophrenia assessed by diffusion tensor imaging has been reported previously. The aim of this preliminary study is to investigate whether cerebral disconnectivity can be detected as early as the first episode of schizophrenia. Intervoxel coherence values were compared by voxel-based t test in 12 patients with first episode schizophrenia and 12 age- and gender-matched control groups. We detected 14 circumscribed significant clusters (P < 0.02), 3 of them with higher, and 11 of them with lower IC values for patients with schizophrenia than for healthy control groups. We interpret these white matter alterations in different regions to be disconnected fiber tracts already present early in schizophrenic disease progression.
先前已有报道称，通过扩散张量成像评估发现，慢性精神分裂症患者存在因白质改变导致的大脑连接中断。这项初步研究的目的是调查大脑连接中断是否能在精神分裂症的首发阶段就被检测到。通过基于体素的t检验比较了12例首发精神分裂症患者和12例年龄及性别匹配的对照组的体素间相干值。我们检测到14个局限性显著簇（P < 0.02），其中3个簇中精神分裂症患者的体素间相干值高于健康对照组，11个簇中精神分裂症患者的体素间相干值低于健康对照组。我们将不同区域的这些白质改变解释为精神分裂症疾病进展早期就已存在的纤维束连接中断。
