1995年至2004年韩国猪群中戊型肝炎病毒的流行情况及基因分型：一项回顾性研究
Prevalence and genotyping of hepatitis E virus in swine population in Korea between 1995 and 2004: a retrospective study.
作者信息
Jung K, Kang B, Song D S, Chae C
机构信息
Department of Veterinary Pathology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Kwanak-Gu 151-742, Seoul, Republic of Korea.
出版信息
Vet J. 2007 May;173(3):683-7. doi: 10.1016/j.tvjl.2006.02.016. Epub 2006 Apr 19.
Hepatitis E virus (HEV) infections have been reported in pigs throughout the world but have only recently been recorded in Korean pigs. The aim of this study was to investigate whether HEV was present in archived porcine hepatic tissues collected between 1995 and 2004 using RT-PCR and immunohistochemistry and, if so, to determine the genotype of the isolates. Swine HEV was identified in the liver tissue of 42 pigs of 388 submissions (four pigs every year on average). The isolates showed genetic homology with swine and human HEV isolates identified in the United States and Japan (92.5-97%) and phylogenetic tree analysis indicated they belonged to genotype III. The study indicates that HEV is not a newly emerging virus in Korean pigs, but a pathogen that has existed in the country since at least 1995.
戊型肝炎病毒（HEV）感染在世界各地的猪中均有报道，但最近才在韩国猪中被记录。本研究的目的是使用逆转录聚合酶链反应（RT-PCR）和免疫组织化学方法，调查1995年至2004年间收集的存档猪肝脏组织中是否存在HEV，如果存在，则确定分离株的基因型。在388份送检样本中的42头猪（平均每年4头）的肝脏组织中鉴定出猪HEV。这些分离株与在美国和日本鉴定出的猪和人HEV分离株具有基因同源性（92.5%-97%），系统发育树分析表明它们属于基因型III。该研究表明，HEV在韩国猪中不是一种新出现的病毒，而是至少自1995年以来就在该国存在的一种病原体。
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